The study examined the relationship of self-efficacy and problem behavior in relation to academic achievement of orthopedically disabled and able-bodied students. Participants were 200 students (100 orthopedically disabled and 100 able-bodied) selected from the inclusive and special schools of Haryana and Chandigarh. Data collected were analyzed using, Correlation, partial correlation and multiple correlations. Results show that self-efficacy positively correlated with academic achievement of orthopedically disabled and able-bodied students.