Salmonella is a facultative intracellular pathogen which is responsible for causing diseases ranging from gastroenteritis to typhoid fever. Multi-drug drug resistant Salmonella spp. is of serious concern that has urged scientists to find alternative medicine. The present study was designed to evaluate the antibacterial activity of methanol extracts of Casuarina equisetifolia, Euphorbia hirta, Euphorbia tirucalli and Sphaeranthus indicus against identified Salmonella species (S. typhi, S. enteritidis and S. paratyphi) using Kirby-Bauer agar well diffusion method. The present study clearly demonstrates that the plants possess strong antimicrobial activity against these Salmonella species. Highest activity was observed in C. equisetifolia mainly against Salmonella typhi.