Heavy metal like mercury (Hg), lead (Pb), arsenic (As), and cadmium (Cd) pose serious health and environmental risks, and modern remediation techniques like chemical precipitation, adsorption, electrochemical treatment, and bioremediation have limitations like high costs, secondary pollution, and efficiency constraints. It's interesting to note that ancient Indian ‘Rasashastra’, a branch of Ayurveda, offers a systematic approach to heavy metal detoxification and transformation through processes like Shodhana (purification), Marana (incineration), and Bhavana (triturating with herbal extracts). These traditional methods use herbal acids, bio-assisted purification, and controlled thermal treatments, which are similar to modern metallurgical and pharmaceutical techniques. Understanding the principles behind these time-tested, eco-friendly techniques may offer innovative solutions for modern heavy metal detoxification, bridging the gap between traditional knowledge and scientific advancements.