The Ayurvedic concept of evolution of disease, based primarily in the understanding of the host-man, meaning of disease without losing sight of either the extrinsic or the intrinsic factors is comprehensive by itself.  Object of Ayurveda is to relieve mankind from diseases and death and to ensure long life - full of health and youthful vigor.  The Ayurveda refers that the Samprapti (Aetiopathogenesis) of any disease is based on the imbalance of three Dosha (Bodily humors) – Vata, Pitta and Kapha. Prior to understand the Samprapti Vighatana (Breaking of Pathogenesis), it is necessary to understand the Vyadhi (Disease) in respect to causes, Accumulation of Dosha, aggravation of Dosha, and distribution of Dosha in various channels, and lastly the manifestation of Dosha.  Vitiated dosha circulate all over the body and become the cause of pathogenesis of a particular disease. The term “Vyadhi-janak Vyapar” is used in Ayurveda for the process of giving birth to a disease.  It is noticeable that Ayurveda refers that the “Samprapti Vighatana” is the Chikitsa (Treatment). Author made an attempt to explore and understanding the Samprapti in context to achieve the positive health and for the treatment of the ailments.